Management of foot burns in a patient with diabetes
“A 44 year old male, Mr M, with type 1 diabetes presented to A & E with burns to his right foot sustained five days earlier by placing the foot on a hot radiator. The patient was a smoker, had long-term poor glycaemic control and had a number of diabetes associated complications including retinopathy and peripheral neuropathy.”
Used with permission of Ark Therapeutics.
Flaminal® Forte; A Clinical Trial to assess the efficacy of use in Partial Thickness Burns
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Peter Campbell, OAM
“Flaminal® Forte was originally developed to manage bio-burden and promote wound healing in chronic wounds. It was found to use a complex of enzymes to destroy the bacterial cell wall whilst not damaging healthy tissue. The RNSH experience with chronic wound healing found Flaminal® Forte was able to make a positive impact on wound progression and healing times.”
A discussion on antimicrobials in chronic wound healing
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Presentation given by Dr Philippe Sollie at GPCE, November 2008
Treatment of four rare & difficult wounds requiring exceptional wound bed preparation
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“Wound bed preparation focuses on debridement, bacterial balance (management of wound exudates) and the overall health status of the patient. Its ultimate aim is to ensure a good granulation tissue leading to complete closure. In this article, we would like to present the wound care regimes for two patients suffering from rare and potentially difficult wounds to treat and heal.” “In each case, the wounds were heavily contaminated with bacteria i.c. MRSA, Enterobacter sp., Proteus sp., loaded with necrotic tissue and required an exceptional level of cleaning and wound bed preparation before further treatment could progress. Cleaning in each case was carried out using chlorhexidine gluconate 0.05% hydrotherapy and a hydro-alginate gel, Flaminal®. In both cases, the wounds were notably cleaner within a week and the wound care regime could be reduced. Wound bed preparation was such that further treatment i.e. skin grafting could be performed after four weeks.
A novel method of comparing the healing properties of two hydrogels in chronic leg ulcers
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M de la Brassinne, L Thirion, L-IL Horvat
“A clinical pilot study using original methods was undertaken to compare the healing properties of the alginate gel Flaminal® (test) and the hydrocolloid gel Intrasite® (control) on chronic leg ulcers. The study was performed over a period of 28 days with two parallel groups of 10 patients. Both the surface (acetate tracing and planimetry) and the volume (Jeltrate® mould impression and weighting) of each wound were measured at baseline and after 7, 14 and 28 days of treatment. On both parameters results were superior with the test product compared to the control, with volume reduction being the first parameter to change.”
Open-label evaluation of an alginates hydrogel in the treatment of leg ulcers
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F. LaCarrubba, L Patania & G Micali
“In conclusion our results, although preliminary, suggest that the tested product is well tolerated and capable of promoting wound healing in addition to protecting the wound from opportunistic infections.”
Evaluation of the Antibacterial Activity & Toxicity of 2 New Hydrogels: A Pilot Study
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K Vandenbulcke, L-IL Horvat, M De Mil, G Slegers & H Beele
“Flaminal® and Flaminal® Hydro are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal® and Flaminal® Hydro were confirmed in an invitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.”
Flaminal®: A novel approach to wound bioburden control
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Richard White
“It is now widely accepted that wound bioburden, in chronic wounds in particular, will often require control. This is best achieved by the use of appropriate topical agents, available in safe, sustained release, broad-spectrum forms. The ancillary functions, if any, of a topical antimicrobial are becoming important health economic factors. Resistance and its development is also of great interest. The new Flaminal® products are novel formulations with broad-spectrum antimicrobial activity which have the capacity to control exudate and promote rapid wound healing.”
Local treatment of burns: a modern approach
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Henk Hoeksema
“In recent years, much research has been conducted with an aim to optimising the local treatment of second-degree burns. With this category of burn we are not just concerned with closure of the wound, but rather with rapid healing with a good aesthetic and functional end result.”
Differential cell death programmes induced by silver dressings in vitro
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D Van Den Plas, K De Smet, D Lens & P Sollie
“In past decades the gold standard for topical burn treatment was the use of silver sulfadiazine. Due to toxicity caused by the silver, the cream base itself, or a combination of both negatively influencing the wound healing process, the healthcare industry searched for alternatives. Although these have been reported to be a significant improvement, the dressings still show residual cytotoxicity.”
