A discussion on antimicrobials in chronic wound healing
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Presentation given by Dr Philippe Sollie at GPCE, November 2008
A novel method of comparing the healing properties of two hydrogels in chronic leg ulcers
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M de la Brassinne, L Thirion, L-IL Horvat
“A clinical pilot study using original methods was undertaken to compare the healing properties of the alginate gel Flaminal® (test) and the hydrocolloid gel Intrasite® (control) on chronic leg ulcers. The study was performed over a period of 28 days with two parallel groups of 10 patients. Both the surface (acetate tracing and planimetry) and the volume (Jeltrate® mould impression and weighting) of each wound were measured at baseline and after 7, 14 and 28 days of treatment. On both parameters results were superior with the test product compared to the control, with volume reduction being the first parameter to change.”
Open-label evaluation of an alginates hydrogel in the treatment of leg ulcers
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F. LaCarrubba, L Patania & G Micali
“In conclusion our results, although preliminary, suggest that the tested product is well tolerated and capable of promoting wound healing in addition to protecting the wound from opportunistic infections.”
Evaluation of the Antibacterial Activity & Toxicity of 2 New Hydrogels: A Pilot Study
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K Vandenbulcke, L-IL Horvat, M De Mil, G Slegers & H Beele
“Flaminal® and Flaminal® Hydro are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal® and Flaminal® Hydro were confirmed in an invitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.”
Flaminal®: A novel approach to wound bioburden control
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Richard White
“It is now widely accepted that wound bioburden, in chronic wounds in particular, will often require control. This is best achieved by the use of appropriate topical agents, available in safe, sustained release, broad-spectrum forms. The ancillary functions, if any, of a topical antimicrobial are becoming important health economic factors. Resistance and its development is also of great interest. The new Flaminal® products are novel formulations with broad-spectrum antimicrobial activity which have the capacity to control exudate and promote rapid wound healing.”
